| Name of Moderator | Residence | Year | Meeting |
| Rev. Samuel Hanna, D.D. | Belfast | 1840 | Belfast |
| Rev. Henry Cooke, D.D., LL.D. | Belfast | 1841 | Belfast |
| Rev. John Edgar, D.D., (LL.D.) | Belfast | 1842 | Belfast |
| Rev. Robert Stewart, D.D. | Broughshane | 1843 | Belfast |
| Rev. John Brown, D.D. | Aghadowey | 1844 | Londonderry |
| Rev. James Carlisle, D.D. | Dublin | 1845 | Dublin |
| Rev. James Morgan (D.D.) | Belfast | 1846 | Belfast |
| Rev. William McClure | Londonderry | 1847 | Belfast |
| Rev. Henry Jackson Dobbin, D.D. | Ballymena | 1848 | Belfast |
| Rev. John Barnett, D.D. | Moneymore | 1849 | Belfast |
| Rev. William Bailey Kirkpatrick, (D.D.) | Dublin | 1850 | Belfast |
| Rev. John Coulter, D.D. | Gilnahirk | 1851 | Belfast |
| Rev. John Bleckley, A.M. | Monaghan | 1852 | Armagh |
| Rev. Henry William Molyneux, D.D. | Larne | 1853 | Belfast |
| Rev. David Hamilton | Belfast | 1854 | Belfast |
| Rev. Robert Allen, A.M. | Ballina | 1855 | Dublin |
| Rev. Robert Wilson, D.D. | Belfast | 1856 | Belfast |
| Rev. Alexander Porter Gowdy, D.D. | Strabane | 1857 | Belfast |
| Rev. John Johnston, A.M., (D.D.). | Tullylish | 1858 | Londonderry |
| Rev. William Gibson, D.D. | Belfast | 1859 | Dublin |
| Rev. Samuel Marcus Dill, D.D. | Ballymena | 1860 | Belfast |
| Rev. John Macnaughtan, A.M. | Belfast | 1861 | Belfast |
| Rev. Henry Cooke, D.D., LL.D. | Belfast | 1862 | Belfast |
| Rev. John Rogers, (D.D.) | Comber | 1863 | Belfast |
| Rev. John Rogers, (D.D.) | Comber | 1864 | Belfast |
| Rev. David Wilson, D.D. | Limerick | 1865 | Belfast |
| Rev. David Wilson, D.D. | Limerick | 1866 | Belfast |
| Rev. Robert Montgomery | Surat, India | 1867 | Dublin |
| Rev. Charles Lucas Morell, (D.D.) | Dungannon | 1868 | Belfast |
| Rev. Richard Smyth, (D.D.) | Londonderry | 1869 | Belfast |
| Rev. Richard Smyth, (D.D.) | Londonderry | 1870 | Belfast |
| Rev. Lowry Edmonds Berkeley | Lurgan | 1871 | Dublin |
| Rev. William Johnston, (D.D.) | Belfast | 1872 | Belfast |
| Rev. William Johnston, (D.D.) | Belfast | 1873 | Belfast |
| Rev. William Magill, (D.D.) | Cork | 1874 | Belfast |
| Rev. Josias Leslie Porter, D.D., LL.D. | Belfast | 1875 | Londonderry |
| Rev. John Meneely, (D.D.) | Belfast | 1876 | Belfast |
| Rev. George Billis, (D.D.) | Belfast | 1877 | Belfast |
| Rev. T. Witherow, D.D. (LL.D.) | Londonderry | 1878 | Belfast |
| Rev. Robert Watts, D.D., (LL.D.) | Belfast | 1879 | Belfast |
| Rev. Jackson Smyth, D.D. | Armagh | 1880 | Belfast |
| Rev. William Fleming Stevenson, D.D. | Rathgar | 1881 | Dublin |
| Rev. Thomas Young Killen, D.D. | Belfast | 1882 | Belfast |
| Rev. Hamilton Brown Wilson, (D.D.) | Cookstown | 1883 | Belfast |
| Rev. James M. Rogers, M.A. (D.D.) | Londonderry | 1884 | Londonderry |
| Rev. James Weir Whigham, (D.D.) | Ballinasloe | 1885 | Belfast |
| Rev. Robert Ross, (D.D.) | Londonderry | 1886 | Belfast |
| Rev. John Henry Orr, D.D. | Antrim | 1887 | Belfast |
| Rev. Robert John Lynd, B.A. (D.D.) | Belfast | 1888 | Belfast |
| Rev. William Clarke, B.A. | Bangor | 1889 | Belfast |
| Rev. William Park, M.A. (D.D.), LL.D. | Belfast | 1890 | Belfast |
| Rev. N. McA. Brown, D.D. (LL.D.) | Limavady | 1891 | Belfast |
| Rev. R. McCheyne Edgar, M.A. (D.D.) | Dublin | 1892 | Dublin |
| Rev. W. Todd Martin, M.A., D.D., D.Litt. | Belfast | 1893 | Belfast |
| Rev. W. Todd Martin, M.A., D.D., D.Litt. | Belfast | 1894 | Belfast |
| Rev. G. Raphael Buick, M.A., LL.D. | Cullybackey | 1885 | Belfast |
| Rev. Henry McIlree Williamson, D.D. | Belfast | 1896 | Belfast |
| Rev. Matthew Leitch, M.A., D.D., D.Litt. | Belfast | 1897 | Belfast |
| Rev. William Beatty, B.A., (D.D.) | Knock | 1898 | Belfast |
| Rev. David Alex Taylor, M.A. (D.D.) | Belfast | 1899 | Belfast |
| Rev. John McC. Hamilton, A.M., (D.D.) | Dublin | 1900 | Dublin |
| Rev. James Heron, B.A., D.D. | Belfast | 1901 | Belfast |
| Rev. John Edgar Henry, M.A., D.D. | Londonderry | 1902 | Belfast |
| Rev. John MacDermott, M.A., (D.D.) | Belfast | 1903 | Belfast |
| Rev. Samuel Prenter, M.A., D.D., LL.D. | Dublin | 1904 | Dublin |
| Rev. William McMordie, M.A., D.D. | Kilkeel | 1905 | Belfast |
| Rev. William McKean, D.D. | Belfast | 1906 | Belfast |
| Rev. William Davidson, M.A., D.D. | Glennan | 1907 | Belfast |
| Rev. John McIlveen, B.A., D.D. | Belfast | 1908 | Belfast |
| Rev. John Courtenay Clarke, B.A., D.D. | Galway | 1909 | Belfast |
| Rev. John Howard Murphy, M.A., D.D. | Cork | 1910 | Belfast |
| Rev. John Macmillan, B.A., D.D. | Belfast | 1911 | Belfast |
| Rev. Henry Montgomery, M.A., D.D. | Belfast | 1912 | Belfast |
| Rev. William J. Macaulay, B.A., D.D. | Portadown | 1913 | Belfast |
| Rev. James Bingham, M.A., D.D. | Dundonald | 1914 | Belfast |
| Rev. Thomas M. Hamill, M.A., D.D. | Belfast | 1915 | Belfast |
| Rev. Thomas West, B.A., D.D. | Antrim | 1916 | Belfast |
| Rev. John Irwin, M.A., D.D. | Belfast | 1917 | Belfast |
| Rev. James McGranahan, B.A., D.D. | Londonderry | 1918 | Belfast |
| Rev. J.M. Simms, C.B., C.M.G., D.D., LL.D., K.H.C. | Newtownards | 1919 | Belfast |
| Rev. H. Patterson Glenn, A.B. | Bray | 1920 | Belfast |
| Rev. W.J. Lowe, M.A., D.D., LL.D. | Belfast | 1921 | Belfast |
| Rev. W.G. Strahan, D.D. | Newry | 1922 | Belfast |
| Rev. George Thompson, D.D. | Belfast | 1923 | Belfast |
| Rev. R.W. Hamilton, M.A., D.D. | Lisburn | 1924 | Belfast |
| Rev. Thomas Haslett, M.A., D.D. | Ballymena | 1925 | Belfast |
| Rev. R.K. Hanna, M.A., D.D. | Dublin | 1926 | Belfast |
| Rev. James Thompson, B.A., D.D. | Londonderry | 1927 | Belfast |
| Rev. T.A. Smyth, M.A., LL.B., D.D. | Belfast | 1928 | Belfast |
| Rev. J.L. Morrow, M.A., D.D. | Dublin | 1929 | Dublin |
| Rev. Edward Clarke, M.A., D.D. | Strabane | 1930 | Belfast |
| Rev. James G. Paton, M.C., M.A., D.D. | Belfast | 1931 | Belfast |
| Rev. James J. Macauley, B.A., D.D. | Dublin | 1932 | Belfast |
| Rev. William Corkey, M.A., D.D. | Belfast | 1933 | Londonderry |
| Rev. T.M. Johnstone, B.A., D.D. | Belfast | 1934 | Belfast |
| Rev. A.F. Moody, M.A., D.D. | Belfast | 1935 | Belfast |
| Rev. F.W.S. O'Neill, M.A., D.D. | Belfast | 1936 | Belfast |
| Rev. John Waddell, M.A., D.D. | Belfast | 1937 | Belfast |
| Rev. W.J. Currie, B.A., D.D. | Bangor | 1938 | Belfast |
| Rev. Prof. James Haire, M.A., D.D. | Belfast | 1939 | Belfast |
| Rev. J.B. Woodburn, M.A., D.D. | Belfast | 1940 | Belfast |
| Rev. W.A. Watson, M.A., D.D. | Belfast | 1941 | Belfast |
| Rev. W.M. Kennedy, B.A., D.D. | Londonderry | 1942 | Belfast |
| Rev. Phineas McKee, B.A., D.D. | Newry | 1943 | Belfast |
| Rev. Andrew Gibson, M.C., B.A., D.D. | Cork | 1944 | Belfast |
| Rev. Prof. Robert Corkey, P.C., M.A., Ph.D. | Belfast | 1945 | Belfast |
| Rev. Thomas Byers, M.A., D.D. | Dublin | 1946 | Belfast |
| Rev. Robert Boyd, B.A., D.D. | Belfast | 1947 | Belfast |
| Rev. Alfred W. Neill, M.A., D.D. | Armagh | 1948 | Belfast |
| Rev. Gordon D. Erskine, B.A., D.D. | Belfast | 1949 | Belfast |
| Rev. J.H.R. Gibson, O.B.E., M.A., D.D. | Belfast | 1950 | Belfast |
| Rev. Hugh McIlroy, B.A., D.D. | Ryans | 1951 | Belfast |
| Rev. John K.L. McKean, M.A., D.D. | Comber | 1952 | Belfast |
| Rev. Principal J.E. Davey, M.A., D.D. | Belfast | 1953 | Belfast |
| Rev. John Knowles, B.A., D.D. | Tullylish | 1954 | Belfast |
| Rev. James C. Breakey, B.A., D.D. | Belfast | 1955 | Belfast |
| Rev. T.M. Barker, M.A., D.D. | Donegal | 1956 | Belfast |
| Rev. Principal R.J. Wilson, M.A., D.D. | Belfast | 1957 | Belfast |
| Rev. Wm. McAdam, M.A., D.D. | Newry | 1958 | Dublin |
| Rev. T.A.B. Smyth, B.A., D.D. | Dublin | 1959 | Belfast |
| Rev. Austin A. Fulton, M.A., Ph.D., D.D. | Belfast | 1960 | Belfast |
| Rev. W.A.A. Park, M.A., D.D. | Ballygilbert | 1961 | Belfast |
| Rev. John H. Davey, B.A., D.D. | India | 1962 | Belfast |
| Rev. W.A. Montgomery, M.A., D.D. | Londonderry | 1963 | Belfast |
| Rev. James Dunlop, M.A., D.D. | Belfast | 1964 | Belfast |
| Rev. S. James Park, M.A., D.D. | Kingstown | 1965 | Belfast |
| Rev. Alfred Martin, B.A., D.D. | Belfast | 1966 | Belfast |
| Rev. William Boyd, M.A., D.D. | Lisburn | 1967 | Belfast |
| Rev. John H. Withers, B.A., D.D. | Belfast | 1968 | Belfast |
| Rev. John T. Carson, B.A., D.D. | Bangor | 1969 | Dublin |
| Rev. Principal J.L.M. Haire, M.A., M.Th., D.D. | Belfast | 1970 | Belfast |
| Rev. F. Rupert Gibson, B.A., D.D. | Belfast | 1971 | Belfast |
| Rev. R.V.A. Lynas, B.A., D.D. | Larne | 1972 | Belfast |
| Rev. J.W. Orr, B.A., D.D. | Belfast | 1973 | Belfast |
| Rev. G. Temple Lundie, M.A., LL.B., D.D. | Armagh | 1974 | Belfast |
| Rev. G.F.H. Wynne, B.A., D.D. | Londonderry | 1975 | Belfast |
| Rev. A.J. Weir, M.Sc., D.D. | Belfast | 1976 | Belfast |
| Rev. T.A. Patterson, B.A., D.D. | Portaferry | 1977 | Belfast |
| Rev. David Burke, B.A., D.D. | Bangor | 1978 | Belfast |
| Rev. W.M. Craig, M.A., B.D., D.D. | Portadown | 1979 | Belfast |
| Rev. R.G. Craig, B.A., D.D. | Carrickfergus | 1980 | Belfast |
| Rev. John Girvan, B.A., D.D. | Lurgan | 1981 | Belfast |
| Rev. E.P. Gardner, B.A., D.D. | Ballymena | 1982 | Belfast |
| Rev. T.J. Simpson, M.A., LL.B., Dip.Ed., D.D., D.Litt. | Newtownards | 1983 | Dublin |
| Rev. Howard Cromie, M.A., B.D., D.D. | Lisburn | 1984 | Belfast |
| Rev. R. Dickinson, M.A., B.D., Ph.D., Th.D., D.D. | Tobermore | 1985 | Belfast |
| Rev. Prof. John Thompson, B.A., B.D., Ph.D., D.D. | Belfast | 1986 | Belfast |
| Rev. Wm. Fleming, B.A., D.D. | Belfast | 1987 | Belfast |
| Rev. A.W.G. Brown, B.A., B.D., Ph.D., Litt.D., D.D. | Ballycastle | 1988 | Belfast |
| Rev. James A. Matthews, B.A., B.D., D.D. | Lurgan | 1989 | Belfast |
| Rev. Principal R.F.G. Holmes, M.A., M.Litt., D.D. | Belfast | 1990 | Belfast |
| Rev. Rodney Sterritt, B.A., D.D. | Newtownards | 1991 | Dublin |
| Rev. John Dunlop, C.B.E., B.A., B.D., D.D., LL.D. | Belfast | 1992 | Belfast |
| Rev. Andrew R. Rodgers, M.A., D.D. | Dungannon | 1993 | Belfast |
| Rev. David J. McGaughey, B.A., D.D. | Kilkeel | 1994 | Belfast |
| Rev. John Ross, B.A., D.D. | Holywood | 1995 | Belfast |
| Rev. D.H. Allen, M.A., B.D., D.D. | Coleraine | 1996 | Belfast |
| Rev Samuel Hutchinson, B.A., B.D., M.Th., D.D. | Lisburn | 1997 | Belfast |
| Rev. S. John Dixon, B.A., D.D. | Antrim | 1998 | Belfast |
| Rev. John W. Lockington, B.A., B.D., M.Th., Ph.D., D.D. | Larne | 1999 | Belfast |
| Rev. Trevor W.J. Morrow, M.A., B.D., M.Th., Ph.D., D.Litt., D.D. | Lucan | 2000 | Belfast |
| Rev. H.A. Dunlop, B.A., B.D., D.D. | Knock | 2001 | Belfast |
| Rev. R.I. Birney, B.A., B.D., D.Min., D.D. | Ballymena | 2002 | Belfast |
| Rev. I.A. McKay, B.A., B.D., D.D. | Dundonald | 2003 | Belfast |
| Rev. K.N.E. Newell, B.A., B.D., M.Th., D.D. | Belfast | 2004 | Belfast |
| Rev. R.E.H. Uprichard, B.A., B.D., M.Th., Ph.D., D.D. | Ahoghill | 2005 | Belfast |
| Rev. David Clarke, LL.B., B.D., D.D. | Coleraine | 2006 | Belfast |
| Rev. John M. Finlay, B.A., B.D., D.D. | Ballymena | 2007 | Belfast |
| Rev. W. Donald Patton, B.S.Sc., B.D., Ph.D., D.D. | Randalstown | 2008 | Belfast |
| Rev. J.S. Carson, B.Sc., M.A., M.A.R., M.Th., D.D, | Portadown | 2009 | Belfast |
| Rev. T. Norman Hamilton, O.B.E., B.A., B.D., D.D. | Belfast | 2010 | Belfast |
| Rev. Ivan J. Patterson, B.A., M.Th., D.D. | Newcastle | 2011 | Belfast |
| Rev. R.A. Patton, B.A., B.D., D.D. | Ballygilbert | 2012 | Belfast |
| Rev. R.L. Craig, B.A., B.D., D.Min., D.D. | Kilfennan | 2013 | Londonderry |
| Rev. Michael A. Barry, B.A., B.D., D.Min., D.D. | Newry | 2014 | Belfast |
| Rev. D. Ian J. McNie, B.D., D.D. | Ballymoney | 2015 | Belfast |
| Rev. F. P. Sellar B.A., B.D., P.G.C.E., M.Min., D.D. | Bloomfield | 2016 | Belfast |